each click you hear is the result of the discharge of a coil, positioned above the skull when
                      Transcranial Magnetic Stimulation (TMS) was applied



Two different natural movies and derived local stimulation conditions are shown as they were used during one of the experiments. To facilitate inspection, movies are shown at half of the speed (12 Hz) used during the experiments. The right-hand color labels (red/blue) code for condition identity. The monitor covered a visual field of approximately 3040 degrees. - See more at: http://f1000research.com/articles/2-51/v2#sthash.0qbKLqgb.dpuf
TMS (see Wikipedia) is a non-invasive and pain-free method that is increasingly used for the treatment of human neurological disorders.

The movie provides a view of the top surface of the cat brain used as an animal model. VSDI is an imaging method that uses fluorescent dye to track neuronal activity with outstanding spatial and temporal resolutions.
 

Note that the first pulse leads to massive suppression (blue colors) of ongoing activity across a large cortical area.


Each subsequent TMS pulse produced a stepwise increase in activity (red), leading to an excitatory cortical state. Such state may open a time window for plastic reorganization of cortical connections and thus for changes in functionality.


Movies are shown at 6 Hz.

Two different natural movies and derived local stimulation conditions are shown as they were used during one of the experiments. To facilitate inspection, movies are shown at half of the speed (12 Hz) used during the experiments. The right-hand color labels (red/blue) code for condition identity. The monitor covered a visual field of approximately 3040 degrees. - See more at: http://f1000research.com/articles/2-51/v2#sthash.0qbKLqgb.dpuf
Two different natural movies and derived local stimulation conditions are shown as they were used during one of the experiments. To facilitate inspection, movies are shown at half of the speed (12 Hz) used during the experiments. The right-hand color labels (red/blue) code for condition identity. The monitor covered a visual field of approximately 3040 degrees. - See more at: http://f1000research.com/articles/2-51/v2#sthash.0qbKLqgb.dpuf

Reference:
Kozyrev V, Eysel UT, & Jancke D (2014) PNAS 111: 13553-13558. doi:10.1073/pnas.1405508111

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