This is the publication list of the BioMIP group while affiliated with the Ruhr Universität (since April 2004). Also available is the earlier publication list of John S. McCaskill. A ResearchID publication list for McCaskill is also available, currently not including patent applications (9).


Tangen, U., Minero, G.A.S., Sharma, A. Wagler, P.F., Cohen,  R., Raz, O., Marx, T., ben Yehezkel T., and McCaskill, J.S. "DNA-library assembly programmed by on-demand nanoliter droplets from a custom microfluidic chip" Biomicrofluidics, 9(4):044103 (2015) . DOI: 10.1063/1.4926616

Wagler, P.F.,  Minero, G.A.S., Tangen, U., de Vries, J. W., Prusty, D. , Kwak, M. Herrmann, A., and McCaskill, J. S.  "Sequence-specific nucleic acid mobility using a reversible block copolymer gel matrix and DNA amphiphiles (lipid-DNA) in capillary and microfluidic electrophoretic separations" Electrophoresis, accepted, (2015), DOI: 10.1002/elps.201400489

Minero, G.A.S. , Wagler, P.F. , Oughli, A.A.  and McCaskill, J.S.  "Electronic pH switching of DNA triplex reactions" RSC Advances, 5 (35), 27313-27325, (2015). DOI:10.1039/C5RA02628H

Freage, L., Trifonov, A., Tel-Vered, R., Golub, E., Wang, F., McCaskill, J. S., & Willner, I. (2015). Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions. Chemical Science, 6(6), 3544-3549. DOI: 10.1039/C5SC00744E

Tangen, U., Sharma, A., Wagler, P.F., and McCaskill, J. S.  “On demand nanoliter-scale microfluidic droplet dispensing and mixing using a passive microfluidic device" Biomicrofluidics, 9, 014119 (2015).

Wagler, P.F. , Tangen, U., Ott, J., and McCaskill, J.S.  "General-Purpose, Parallel and Reversible Microfluidic Interconnects" IEEE Transactions on Components, Packaging and Manufacturing Technology, 2015, 5(3), 291-300.  DOI:10.1109/TCPMT.2015.2395815

Wills, P., Nieselt, K., & McCaskill, J. S. (2015). "Emergence of Coding and its Specificity as a Physico-Informatic Problem." Origins of Life and Evolution of Biospheres, 45(1-2), 249-255. DOI: 10.1007/s11084-015-9434-5

Sharma, A., & McCaskill, J. S. (2015). Autonomous lablet locomotion and active docking by sensomotory electroosmotic drive. Paper presented at the European Conference on Articial Life, York. DOI: 10.7551/978-0-262-33027-5-ch081

(list for 2015 not yet completed)

Other publications

McCaskill, J.S., Maeke, T., Sharma, A., Wagler, P.F., Funke, D., Mayr, P. and Oehm, J. “MICREAgents: MIcroscopic Chemically Reactive Electronic Agents” 15th European Conference on Artificial Life, York (2015). Poster.

see also Project Deliverables


Patzke, V.,  McCaskill, J.S., v. Kiedrowski, G., "DNA with 3'-5'-Disulfide-links:  Rapid chemical ligation via isosteric replacement” Angewandte Chemie - International Edition 53(16), 4222-4226 (2014). DOI: 10.1002/anie.201310644

Tangen, U.  On evolvability and robustness in the matrix-GRT model. Genetic Programming and Evolvable Machines, 15(3), 343-374 (2014). DOI 10.1007/s10710-014-9221-5

McCaskill, J. S., Amos, M., Dittrich, P., Rasmussen S. . (2014). A Roadmap for Chemical and Biological Information Technology: ChemBioIT. 1-164. Retrieved from http://www.cobra-project-eu website: http://www.cobra-project-eu/uploads/2/0/8/9/20895162/cobra_d2.3_draft_roadmap.pdf.

Other publications

Tangen, U., Minero, G.K.A., Sharma, A., Maeke, T., Wagler, P.F., McCaskill, J. S. , "Programmable DNA recombinant synthesis in nl scale microfluidics.  External Review Meeting, RUB, Faculty of Chemistry and Biochemistry (2014) CADMAD Poster.

Tangen, U., "How is new information being created?" MPI Winterseminar on 'Biophysical Chemistry', Klosters, Switzerland (2014). MICREAgents Poster.


Bedau, M.A., McCaskill, J.S., Packard, N.H.,  Parke, E., Rasmussen, S. , “Introduction to recent developments in Living Technology” 19, 291-293 (2014). DOI:  10.1162/ARTL_e_00121

Other publications

Tangen, U., Sharma, A., Maeke, T., Wagler, P.,  McCaskill, J.S. "On separation in microfluidic structures." MPI Winterseminar on 'Biophysical Chemistry', Klosters, Switzerland. (2013) CADMAD Project Poster

Sharma, A., Minero, G.K.A.,  McCaskill, J.S. "Electronically controlled fast DNA switches in microfluidic devices.  4th Junges Chemie Symposium, MPI Mülheim, (2013) Poster.

Oehm, J. & AIS group, McCaskill,J.S., & BioMIP group, Mayr, P. & IS group ”MICREAGents Electronic Development” RUB Engineering Professorium: 'Alles Ing’ Bochum (2013) Poster.

McCaskill, J.S., Wagler, P., Minero, G.K.A., Tangen, U., Sharma, A., Maeke, T.   "Programming Chemistry with Addressable Chemtainers”, External Review Meeting. RUB Faculty of Chemistry and Biochemistry (2013) Poster. 


Wagler, P., Tangen, U., Maeke,T., McCaskill, J. S. "Field programmable chemistry: Integrated chemical and electronic processing of informational molecules towards electronic chemical cells.” Biosystems 109, 2-17, (2012). DOI: 10.1016/j.biosystems.2012.01.005

McCaskill, J.S. "Microscale Chemically Reactive Electronic Agents” International Journal of Unconventional Computation, 8, 288-299. (2012). link

Other publications

Sharma, A., Maeke, T., Wagler P.,  and McCaskill, J.S. "Conventional LCoS chips for future biochemical applications: Experiments and theory."  8th international meeting on electrowetting, 2012 (2012). Poster. 

Minero, G.K.A., Wagler, P.F.,  and McCaskill, J. S. "Electronically switchable DNA hybridization via triplex interactions." 18th International Conference on DNA Computing and Molecular Programming, DNA18 (2012). Poster.

Birch, H., McCaskill, J.S., "Life, but not as we know it." Chemistry World, an interview with John McCaskill (2012) link


Amos, M., Dittrich, P., McCaskill, J., & Rasmussen, S. (2011). Biological and Chemical Information Technologies. Proceedings of the 2nd European Future Technologies Conference and Exhibition 2011 (Fet 11), 7, 56-60. DOI: 10.1016/j.procs.2011.12.019

Other publications

Minero, G. K.A., and McCaskill, J. S.  "Monitoring and fast analysis of triplex formation"  JCS-Ruhr 2011 Book of Abstracts 2011 8, 36 (2011) . MATCHIT Poster.

Minero, G. K.A., "Murine DNA methyltransferase Dnmt3a: probing of DNA-enzyme interactions with benzo[a]pyrene-containing DNA by fluorescence." DECHEMA Biotransformations 2011, Book of Abstracts (2011) Poster.


Bedau, M.A., McCaskill, J.S., Packard, N.H., Rasmussen, S. ”Living technology: Exploiting life's principles in technology”, Artificial Life (2010), vol 16(1) , 89-97. DOI: 10.1162/artl.2009.16.1.16103

McCaskill, J.S. ”Living technology: 5 Questions” in Bedau, M.A. et al (eds.) ”Living technology: 5 Questions”,  pp 111-121 (2010) Automatic Press. ISBN-10 89-92130-29-1.

Tangen, U. “Enzyme-like replication de novo in a micro-controller”, Artificial Life, 16(4), 311-328, ( 2010).  DOI: 10.1162/artl_a_00012

Tangen, U. "The emergence of replication in a digital evolution system using a secondary structure approach.”,  Alife 12 Conf. Proc., MIT Press, Cambridge, USA, pp. 168-175. link


Füchslin, R.M., Maeke, T., McCaskill, J.S. “Spatially resolved simulation of membrane reactions and dynamics: Multipolar reaction DPD”, Eur. Phys. J.E. 29, 413-448 (2009), DOI 

Bedau, M.A., Parke, E.C.,  Tangen, U., Hantsche-Tangen, B. “Social and ethical checkpoints for bottom-up synthetic biology, or protocells”, Syst. Synth. Biol. 3, 65-75 (2009), DOI 10.1007/s11693-009-9039-2

Füchslin, R. M., Fellermann, H., Eriksson, A., & Ziock, H.-J.  "Coarse graining and scaling in dissipative particle dynamics." Journal of Chemical Physics, 130(21), 214102 (2009). DOI : 10.1063/1.3143976


McCaskill, J.S.  in: “Protocells: Bridging nonliving and living matter”, ed. by S. Rasmussen et al., MIT Press Cambridge, Mass., London, England  (2008) pp. 253-295. Evolutionary microfluidic complementation toward artificial cells.;=11630

Chemnitz, S., Tangen, U., Wagler, P. F., Maeke, T., McCaskill, J. S., Electronically programmable membranes for improved biomolecule handling in micro-compartments on-chip, Chemical Engineering Journal 135S, (2008) 276-9.

Füchslin, R. M., Eriksson, A., Fellermann, H., Ziock, H., Coarse-graining and scaling in dissipative particle dynamics, Journal of Chemical Physics submitted, (2008).

Rasmussen, S., Bedau, M.A., McCaskill, J.S. , Packard, N.  in “Protocells: Bridging nonliving and living matter”, ed. by S. Rasmussen et al., MIT Press Cambridge, Mass., London, England  (2008) pp. 71-101. A roadmap to protocells.

McCaskill JS, Packard NH, Rasmussen S, von Kiedrowski G, Poli I, Nielsen P, Lindgren K, Solé R, Pfeifer R, Tamulis A, Mouritsen O, Eggenberger P, McMullin B, Bedau MA "The PACE Report" (2008)

Other publications

Tangen, U., “Declaration of the external interface between the ng_biopro-software and another external control-program, version 0.49 enhanced command 's'”  (2008).


McCaskill, J., Packard, N. H., Rasmussen, S., Bedau, M. A., Evolutionary self-organization in complex fluids, Phil. Trans. Roy. Soc. Lond. ser. B 362, (2007) 1763-79.

Tangen, U., From evolving software towards models of dynamically self-assembling processing systems,  paper presented at the Proceedings of ECCS 2006 (2007). link  pdf

Wagler, P. F., Hempelmann, W., Programmierbare Flüsse in Mikrofluidikchips, GIT Labor-Fachzeitschrift, (2007) 736.

Other publications

Bagheri-Maurer, J., Wagler, P. F., “How to fill fpfa chip modules, version 30 may '07: Operations-manual (how to use the fpfa and biomodule resp.)”  (2007).

Maeke, T., “Hardware-manual of bio@fox, biopro-hardware-manual revision 0.13”  (2007).

Tangen, U., “User's-manual of biopro-software, users- and programmers-manual version 0.2”  (2007).


Füchslin, R., Maeke, T., Tangen, U., McCaskill, J. S., Evolving inductive generalization via genetic self-assembly, Advances in Complex Systems 9, (2006) 1-29.

Tangen, U. Wagler, P. F., Chemnitz, S., Goranovic, G., Maeke, T., McCaskill, J. S., An electronically controlled microfluidics approach towards artificial cells., CompPlexUs 3, (2006) 48-57.

Chemnitz, S., Tangen, U., Wagler, P. F., Maeke, T., McCaskill, J. S., Electronically programmable membranes for improved biomolecule handling in micro-compartments on-chip  paper presented at the 9th International Conference on Microreaction Technology (IMRET 9) 2006.

Other publications

Chemnitz, S., Ph.D., Univ. Saarland, Advisors: McCaskill, J. S., Seidel, H. (2006) "Hybrid microfludic systems as a programmable environment to study biochemical model reactions."


Tangen, U., Wagler, P.F., Chemnitz, S, Goranovic, G, Maeke, T., McCaskill, J. S., An electronically controlled microfluidics approach towards artificial cells  paper presented at the European Conference on Complex Systems 2005.

McCaskill, J. S., Ehses, S. et al., Stationary chemical gradient reactors in the search for artificial cells  paper presented at the MicroTas 2005, Boston 2005.

Wagler, P. F. et al., Dynamical multiphase structures in the microsystem approach to artificial cells  paper presented at the MicroTas 2005 Boston, 2005.

Wagler, P., Tangen, U, Maeke, T, Chemnitz, S, Jünger, M and McCaskill, J.S., Molecular systems on-chip (msoc) - steps forward for programmable biosystems  paper presented at the SPIE: Smart Structures and Materials 2004 (San Diego, CA, USA) 2005.

Ehses, S., Ackermann, J., McCaskill, J. S., Optimization and design of oligonucleotide setup for strand displacement amplification, J Biochem Biophys Methods 63, (Jun 30, 2005) 170-86.;=PubMed&dopt;=Citation&list;_uids=15975661 

Ehses, S., Ph. D. Thesis, Ruhr-Universität Bochum, Advisors: McCaskill, J. S., Kiedrowski, G. v. (2005) "Isothermal in vitro selection and amplification to investigate evolution processes."

Rücker, T., Ph.D. Thesis, University of Bonn, Advisors: McCaskill, J. S., Famulok, M. (2005). "Biomolecular information processing in networked microflow reactors." 

2004 (RUB)

Chemnitz, S., M. Jünger, et al. (2004). Hybrid BioModules Based on Printed Circuit Board Technology. Chemische und biologische Mikrolabortechnik, Ilmenau, Germany.

Füchslin, R. M., S. Altmeyer, McCaskill, JS (2004). "Evolutionary stabilization of generous replicases by complex formation." Europ. Phys J. 38(1): 103-110.

Schäfer, H., S. Chemnitz, et al. (2004). A New Technology for an Application Specific Lab-on-Microchip. The Nano-Micro Interface. H. J. Fecht and M. Werner. Weinheim, Wiley: 119-137.

Van Noort, D. and McCaskill, JS.  (2004). "Flows in micro fluidic networks: From theory to experiment." Natural Computing 3(4): 395.

Wagler, PF., Tangen, U., Maeke, T., Chemnitz, S., Jünger, M., McCaskill, JS (2004). Molecular systems on-chip (MSoC) - steps forward for programmable biosystems. SPIE: Smart Structures and Materials 2004, San Diego, CA, USA, Proceedings of SPIE. Vol 5389 - Smart Structures and Materials 2004: Smart Electronics, MEMS, BioMEMS, and Nanotechnology, 298:305

Wagler, PF., Tangen, U., Maeke, T., Chemnitz, S., Jünger, M., McCaskill, JS (2004). Molecular Systems on a chip: Steps forward for programmable Biosystems. 2nd Workshop Proceedings: Chemische und biologische Mikrolabortechnik, Ilmenau.



RUB 2015.  Copyright 2007-2013. All rights reserved. Web managers: J. S. McCaskill, T. Maeke.