Benjamin Born

Dr. Benjamin Born

Irit Sagi's Lab
Dept. of Biological Regulation
WIS logo
Rehovot 76100, Israel
 phone: +972–8–934–2188
 e-mail: benjamin.born[at]
* RUB-alumni e-mail: benjamin.born[at] *

From hydration shells to extracellular design

Since August 2010, I am a postdoctoral fellow in Irit Sagi's lab at the Weizmann Institute of Science. My research interests range from spectroscopic hydration studies of bio-solutes in equilibrium and under perturbation conditions to imaging of proteins and cellular processes related to extracellular-matrix remodeling.
My research aim is to understand the role of water in biological systems on the molecular level and to reveal mechanistic details of tissue remodeling by combining a variety of biophysical techniques.


Honors & Awards



© B. Born, WIS (2014)

  Protein Stabilization by Macromolecular Crowding
  through Enthalpy rather than Entropy

  M. Senske, L. Törk, B. Born, M. Havenith, C. Hermann, S. Ebbinghaus
  Journal of the American Chemical Society,

© B. Born, WIS (2013)

  Probing solvation dynamics by THz absorption spectroscopy
  B. Born, M. Heyden, S. Ebbinghaus, M. Havenith
  in Terahertz Biomedical Science and Technology,
  CRC Press, 377 pages (2014)

  ISBN: 9781466570443

© J. Dielmann, PC2 (2013)

  Kinetic Terahertz Absorption Spectroscopy of Protein Solutions
  J. Dielmann, V. Conti Nibali, B. Born, E. Bründermann, M. Havenith
  IRMMW–THz Conference (2013)
  DOI: 10.1109/IRMMW-THz.2013.6665564

© B. Born, WIS (2013)

  Protein-water network dynamics during metalloenzyme hydrolysis
  observed by kinetic THz absorption (KITA)

  B. Born, M. Heyden, M. Grossman, I. Sagi, M. Havenith
  Proceedings of SPIE 858513, 8585131–85851317 (2013)
  DOI: 10.1117/12.2000715

© B. Born, WIS (2012)

  Zn2+–Aß40 complexes form metastable quasi-spherical oligomers that
  are cytotoxic to cultured hippocampal neurons

  I. Solomonov*, E. Kokortian*, B. Born, Y. Feldman, A. Bitler, F. Rahimi, H. Li,
  G. Bitan, I. Sagi
  Journal of Biological Chemistry 287, 20555–20564 (2012)
  DOI: 10.1074/jbc.M112.344036
  * authors contributed equally

© B. Born, WIS (2011)

  Water's contribution and enzyme's work – a KITA study
  B. Born, I. Sagi, M. Havenith
  Proceedings of SPIE 8225, 822518/1–822518/7 (2012)
  DOI: 10.1117/12.907770

© B. Born, WIS (2011)

  Correlated structural kinetics and retarded solvent dynamics at the
  metalloprotease active site

  M. Grossman*, B. Born*, M. Heyden*, D. Tworowski, G.B. Fields,
  I. Sagi**, M. Havenith**
  Nature Structural & Molecular Biology 18(10), 1102–1108 (2011)
  DOI: 10.1038/nsmb.2021
  * authors contributed equally   ** corresponding authors contributed equally

© B. Born, PC2 (2011)

  Antifreeze Glycoprotein Activity Correlates with Long–Range
  Protein–Water Dynamics

  S. Ebbinghaus, K. Meister, B. Born, A.L. DeVries, M. Gruebele, M. Havenith
  Journal of the American Chemical Society 132(35), 12210–12211 (2010)
  DOI: 10.1021/ja1051632

© B. Born, PC2 (2011)

  Hydration Dynamics of Proteins Probed by Terahertz Spectroscopy
  B. Born, M. Heyden, M. Havenith
  IRMMW–THz Conference (2010)
  DOI: 10.1109/ICIMW.2010.5612694

© B. Born, PC2 (2010)

  Using Rattling Ions to Probe sub–ps Water Network Dynamics
  D. A. Schmidt, Ö. Birer, S. Funkner, B. Born, R. Gnanasekaran, G. Schwaab,
  D. Leitner, M. Havenith
  IRMMW–THz Conference (2010)
  DOI: 10.1109/ICIMW.2010.5612708

© M. Heyden, PC2 (2010)

  Solvation water of biomolecules seen through THz glasses
  M. Heyden, B. Born, M. Havenith
  IRMMW–THz Conference (2010)
  DOI: 10.1109/ICIMW.2010.5612303

© B. Born, PC2 (2010)

  Terahertz Spectroscopy of Proteins – Hydration Dynamics of Proteins
  during Folding, Enzyme Catalysis and in Chemical Equilibrium

  B. Born
  Ph.D. Thesis, Ruhr–University Bochum, 141 pages
  Südwestdeutscher Verlag für Hochschulschriften, 168 pages (2010)
  ISBN–10: 3838121473

© B. Born, PC2 (2009)

  Rattling in the cage: ions as probes of sub–ps water network dynamics
  D.A. Schmidt, Ö. Birer, S. Funkner, B. Born, R. Gnanasekaran, G. Schwaab,
  D. Leitner, M. Havenith
  Journal of the American Chemical Society 131(51), 18512–18517 (2009)
  DOI: 10.1021/ja9083545

© B. Born, PC2 (2009)

  Terahertz dance of proteins and sugars with water
  B. Born, M. Havenith
  Journal of Infrared, Millimeter and Terahertz Waves 30(12), 1245–1254 (2009)
  DOI: 10.1007/s10762-009-9514-6

© B. Born, PC2 (2009)

  Solvation Dynamics of Model Peptides Probed by Terahertz Spectroscopy.
  Observation of the Onset of Collective Network Motions

  B. Born, H. Weingärtner, E. Bründermann, M. Havenith
  Journal of the American Chemical Society 131(10), 3752–3755 (2009)
  DOI: 10.1021/ja808997y

© B. Born, PC2 (2009)

  Terahertz spectroscopic techniques for the study of proteins in aqueous

  E. Bründermann, B. Born, S. Funkner, M. Krüger, M. Havenith
  Proceedings of SPIE 7215, 72150E1–72150E9 (2009)
  DOI: 10.1117/12.808270

© B. Born, PC2 (2009)

  The Terahertz dance of water with the proteins: The effect of protein
  flexibility on the dynamical hydration shell of ubiquitin

  B. Born, S.J. Kim, S. Ebbinghaus, M. Gruebele, M. Havenith
  Faraday Discussions 141, 161–173 (2009)
  DOI: 10.1039/b804734k

  • Selected for RSC's Chemical Biology Research Articles virtual journal
  • One of the Top 10 most downloaded articles in July 2009

© M. Heyden, PC2 (2008)

  Real–time detection of protein–water dynamics upon protein folding
  by Terahertz absorption

  S.J. Kim, B. Born, M. Havenith, M. Gruebele
  Angewandte Chemie International Edition 47(34), 6486–6488 (2008)
  DOI: 10.1002/anie.200802281

  Echtzeit–Nachweis von Änderungen im Protein–Wassernetzwerk während
  der Proteinfaltung mit Hilfe von Terahertz–Absorptionsspektroskopie

  S.J. Kim, B. Born, M. Havenith, M. Gruebele
  Angewandte Chemie 120(34), 6586–6588 (2008)
  DOI: 10.1002/ange.200890220

© E. Bründermann,

  Terahertz Imaging Applications in Spectroscopy of Biomolecules
  E. Bründermann, U. Heugen, R. Schiwon, B. Born, G.W. Schwaab,
  S. Ebbinghaus, K. Schröck, D.R. Chamberlin, E.E. Haller, M. Havenith
  Microwave Symposium Digest IEEE MTT–S International, 625–628 (2005)
  DOI: 10.1109/MWSYM.2005.1516679

© B. Born, PC2 (2005)

  Ultrasensitive Detection of Proteins in Aqueous Solution by
  Terahertz Absorption Spectroscopy

  B. Born
  Diploma Thesis, Ruhr–University Bochum, 94 pages (2005)

       Honors and Awards     

  Falling Walls Lab
  finalist (2013)
   supported by A.T. Kearney

  63rd Lindau Nobel Laureate Meeting
  selectee (2013)
   supported by the Human Frontier Science Program
   and the Verband der Chemischen Industrie e.V.

  Cross–Disciplinary Fellowship 2011
  of the Human Frontier Science Program for
  Postdoctoral Fellows (2011–2014)

  Dean of Faculty Fellowship
  of the Weizmann Institute of Science for
  Postdoctoral Fellows (2010–2011)

  Ruhr–University Research School Fellowship
  for Graduate Students (2007–2010) funded by
  Germany's Excellence Initiative [DFG GSC 98/1]

  Bronnbacher Scholarship
  by the Culture Group of the Federation of
  German Industries (BDI) in 2008/09

  Short-term Scholarship
  for Graduate Students by the German Academic
  Exchange Service (March–May 2007)


Homepages Essays Comments Water in Biology

     * last update: 15-06-2014 * Contact: Benjamin Born *