Functional genomics of fungal morphogenesis: Publications

Publication list Minou Nowrousian

Peer-reviewed research articles


Lütkenhaus R, Breuer J, Nowrousian M (2021) Functional characterization of the developmental genes asm2, asm3, and spt3 required for fruiting body formation in the filamentous ascomycete Sordaria macrospora. Genetics (in press) Paper at Genetics

Harting R, Starke J, Kusch H, Pöggeler S, Maurus I, Schlüter R, Landesfeind M, Bulla I, Nowrousian M, de Jonge R, Stahlhut G, Hoff KJ, Aßhauer KP, Thürmer A, Stanke M, Daniel R, Morgenstern B, Thomma BPHJ, Kronstad JW, Braus-Stromeyer SA, Braus GH (2021) A 20-kb lineage-specific genomic region tames virulence in pathogenic amphidiploid Verticillium longisporum. Mol Plant Pathol (in press) Paper at Mol. Plant Pathol.

Asseck LY, Mehlhorn DG, Rivera Monroy J, Ricardi MM, Breuninger H, Wallmeroth N, Berendzen KW, Nowrousian M, Xing S, Schwappach B, Bayer M, Grefen C (2021) Endoplasmic reticulum membrane receptors of the GET pathway are conserved throughout eukaryotes. Proc Nat Acad Sci USA 118: e2017636118 Paper at PNAS


Kölle M, Horta MAC, Nowrousian M, Ohm RA, Benz JP, Pilgård A (2020) Degradative capacity of two strains of Rhodonia placenta: from phenotype to genotype. Front Microbiol 11: 1338 Paper at Frontiers in Microbiology

Fang YF, Coelho MA, Shu H, Schotanus K, Thimmappa BC, Yadav V, Chen H, Malc EP, Wang J, Mieczkowski PA, Kronmiller B, Tyler BM, Sanyal K, Dong S, Nowrousian M, Heitman J (2020) Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages. PLoS Genet 16: e1008646 Paper at PLoS Genetics


Lütkenhaus R, Traeger S, Breuer J, Carreté L, Kuo A, Lipzen A, Pangilinan J, Dilworth D, Sandor L, Pöggeler S, Gabaldón T, Barry K, Grigoriev IV, Nowrousian M (2019) Comparative genomics and transcriptomics to analyze fruiting body development in filamentous ascomycetes. Genetics 213: 1545-1563 Abstract Paper at Genetics

Blank-Landeshammer B, Teichert I, Märker R, Nowrousian M, Kück U, Sickmann A (2019) Combination of proteogenomics with peptide de novo sequencing identifies new genes and hidden posttranscriptional modifications. mBio 10: e02367-19 Paper at mBio

Sun S, Coelho MA, Heitman J, Nowrousian M (2019) Convergent evolution of linked mating-type loci in basidiomycete fungi. PLoS Genet 15: e1008365 Paper at PLoS Genetics

Passer AR, Coelho MA, Billmyre RB, Nowrousian M, Mittelbach M, Yurkov AM, Averette AF, Cuomo CA, Sun S, Heitman J (2019) Genetic and genomic analyses reveal boundaries between species closely related to Cryptococcus pathogens. mBio 10:e00764-19 Paper at mBio


Schumacher DI, Lütkenhaus R, Altegoer F, Teichert I, Kück U, Nowrousian M (2018) The transcription factor PRO44 and the histone chaperone ASF1 regulate distinct aspects of multicellular development in the filamentous fungus Sordaria macrospora. BMC Genetics 19: 112 Paper at BMC Genetics

Murat C, Payen T, Noel B, Kuo A, Morin E, Chen J, Kohler A, Krizsán K, Balestrini R, Da Silva C, Montanini B, Hainaut M, Levati E, Barry KW, Belfiori B, Cichocki N, Clum A, Dockter RB, Fauchery L, Guy J, Iotti M, Le Tacon F, Lindquist EA, Lipzen A, Malagnac F, Mello A, Molinier V, Miyauchi S, Poulain J, Riccioni C, Rubini A, Sitrit Y, Splivallo R, Traeger S, Wang M, Žifcáková L, Wipf D, Zambonelli A, Paolocci F, Nowrousian M, Ottonello S, Baldrian P, Spatafora JW, Henrissat B, Nagy LG, Aury J-M, Wincker P, Grigoriev IV, Bonfante P, Martin FM (2018) Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal truffle lifestyle. Nat Ecol Evol 2: 1956-1965 Paper at Nature Ecology & Evolution

Yu Y, Blachowicz A, Will C, Szewczyk E, Glenn S, Gensberger-Reigl S, Nowrousian M, Wang CCC, Krappmann S (2018) Mating-type factor-specific regulation of the fumagillin/pseurotin secondary metabolite supercluster in Aspergillus fumigatus. Mol Microbiol 110: 1045-1065 Abstract

Mark MD, Donner M, Eickelbeck D, Stepien J, Nowrousian M, Kück U, Paris F, Hellinger J, Herlitze S (2018) Visual tuning in the flashlight fish Anomalops katoptron to detect blue, bioluminescent light. PLoS One 13: e0198765 Paper at PLoS ONE

Senges CHR, Al-Dilaimi A, Marchbank DH, Wibberg D, Winkler A, Haltli B, Nowrousian M, Kalinowski J, Kerr RG, Bandow JE (2018) The secreted metabolome of Streptomyces chartreusis and implications for bacterial chemistry. Proc Natl Acad Sci USA 115: 2490-2495 Paper at PNAS


Sun S, Yadav V, Billmyre RB, Cuomo CA, Nowrousian M, Wang L, Souciet JL, Boekhout T, Porcel B, Wincker P, Granek JA, Sanyal K, Heitman J (2017) Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination. PLoS Biol. 2017 15: e2002527 Paper at PLoS Biology

Teichert I, Dahlmann T, Kück U, Nowrousian M (2017) RNA editing during sexual development occurs in distantly related filamentous ascomycetes. Genome Biol Evol 9: 855-868 Paper at Genome Biology and Evolution

Sukul P, Schäkermann S, Bandow JE, Kusnezowa A, Nowrousian M, Leichert LI (2017) Simple discovery of bacterial biocatalysts from environmental samples through functional metaproteomics. Microbiome 5:28, doi: 10.1186/s40168-017-0247-9 Paper at Microbiome

Nguyen TA, Cissé OH, Wong JY, Zheng P, Hewitt D, Nowrousian M, Stajich JE, Jedd G (2017) Innovation and constraint leading to complex multicellularity in the Ascomycota. Nat Commun 8:14444, doi: 10.1038/ncomms14444 Paper at Nature Communications

Teichert I, Lutomski M, Märker R, Nowrousian M, Kück U (2017) New insights from an old mutant: SPADIX4 governs fruiting body development but not hyphal fusion in Sordaria macrospora. Mol Genet Genomics 292: 93-104 Abstract


Nowrousian M (2016) Complete mitochondrial genome sequence of the Pezizomycete Pyronema confluens. Genome Announc 4: e00355-16 Paper at Genome Announcements


Traeger S, Nowrousian M (2015) Analysis of circadian rhythms in the basal filamentous ascomycete Pyronema confluens. G3 (Bethesda) 5: 2061-2071 Paper at G3

Kourist R, Bracharz F, Lorenzen J, Kracht ON, Chovatia M, Daum C, Deshpande S, Lipzen A, Nolan M, Ohm RA, Grigoriev IV, Sun S, Heitman J, Brück T, Nowrousian M (2015) Genomics and transcriptomics of the oil-accumulating basidiomycete yeast Trichosporon oleaginosus: insights into substrate utilization and alternative evolutionary trajectories of fungal mating systems. mBio 6: e00918-15 Paper at mBio

Traeger S, Nowrousian M (2015) Functional analysis of developmentally regulated genes chs7 and sec22 in the ascomycete Sordaria macrospora. G3 (Bethesda) 5: 1233-1245 Paper at G3 low resolution pdf

Wolfers S, Kamerewerd J, Nowrousian M, Sigl C, Zadra I, Kürnsteiner H, Kück U, Bloemendal S (2015) Microarray hybridization analysis of light-dependent gene expression in Penicillium chrysogenum identifies bZIP transcription factor PcAtfA. J Basic Microbiol 55: 480-489 Abstract


Schwartze VU, Winter S, Shelest E, Marcet-Houben M, Horn F, Wehner S, Linde J, Valiante V, Sammeth M, Riege K, Nowrousian M, Kaerger K, Jacobsen ID, Marz M, Brakhage AA, Gabaldón T, Böcker S, Voigt K (2014) Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial Mucorales (Mucoromycotina). PLoS Genet 10: e1004496 Abstract Paper at PLoS Genetics

Schindler D, Nowrousian M (2014) The polyketide synthase gene pks4 is essential for sexual development and regulates fruiting body morphology in Sordaria macrospora. Fungal Genet Biol 68: 48-59 Abstract

Dirschnabel DE, Nowrousian M, Cano-Domínguez N, Aguirre J, Teichert I, Kück U (2014) New insights into the roles of NADPH oxidases in sexual development and ascospore germination in Sordaria macrospora. Genetics 196: 729-744 Abstract


Nowrousian M (2013) Fungal gene expression levels do not display a common mode of distribution. BMC Res Notes 6: 559 low resolution pdf

Traeger S, Altegoer F, Freitag M, Gabaldon T, Kempken F, Kumar A, Marcet-Houben M, Pöggeler S, Stajich JE, Nowrousian M (2013) The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution. PLoS Genet 9: e1003820 Paper at PLoS Genetics low resolution pdf

Gesing S, Schindler D, Nowrousian M (2013) Suppression subtractive hybridization and comparative expression analysis to identify developmentally regulated genes in filamentous fungi. J Basic Microbiol 53: 742-751 Abstract


Teichert I, Wolff G, Kück U, Nowrousian M (2012) Combining laser microdissection and RNA-seq to chart the transcriptional landscape of fungal development. BMC Genomics 13: 511 low resolution pdf

Gesing S, Schindler D, Fränzel B, Wolters D, Nowrousian M (2012) The histone chaperone ASF1 is essential for sexual development in the filamentous fungus Sordaria macrospora. Mol Microbiol 84: 748-765 Abstract

Nowrousian M, Teichert I, Masloff S, Kück U (2012) Whole-genome sequencing of Sordaria macrospora mutants identifies developmental genes. G3 (Bethesda) 2: 261-270 Paper at G3 low resolution pdf

Wilms I, Overlöper A, Nowrousian M, Sharma CM, Narberhaus F (2012) Deep sequencing uncovers numerous small RNAs on all four replicons of the plant pathogen Agrobacterium tumefaciens. RNA Biol 9: 446-457 Abstract pdf


Klix V, Nowrousian M, Ringelberg C, Loros JJ, Dunlap JC, Pöggeler S (2010) Functional characterization of MAT1-1-specific mating-type genes in the homothallic ascomycete Sordaria macrospora provides new insights into essential and non-essential sexual regulators. Eukaryot Cell 9: 894-905 Abstract

Nowrousian M, Stajich JE, Chu M, Engh I, Espagne E, Halliday K, Kamerewerd J, Kempken F, Knab B, Kuo HC, Osiewacz HD, Pöggeler S, Read ND, Seiler S, Smith KM, Zickler D, Kück U, Freitag M (2010) De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis. PLoS Genet 6(4): e1000891 Paper at PLoS Genetics pdf companion perspective article


Nowrousian M (2009) A novel polyketide biosynthesis gene cluster is involved in fruiting body morphogenesis in the filamentous fungi Sordaria macrospora and Neurospora crassa. Curr Genet 55: 185-198 Abstract


Kamerewerd J*, Jansson M*, Nowrousian M, Pöggeler S, Kück U (2008) Three alpha subunits of heterotrimeric G proteins and an adenylyl cyclase have distinct roles in fruiting body development in the homothallic fungus Sordaria macrospora. Genetics 180: 191-206. *equal contribution Abstract Cover story


Engh I, Nowrousian M, Kück U (2007) Regulation of melanin biosynthesis via the dihydroxynaphthalene pathway is dependent on sexual development in the ascomycete Sordaria macrospora. FEMS Microbiol Lett 275: 62-70 Abstract

Nowrousian M, Frank S, Koers S, Strauch P, Weitner T, Ringelberg C, Dunlap JC, Loros JJ, Kück U (2007) The novel ER membrane protein PRO41 is essential for sexual development in the filamentous fungus Sordaria macrospora. Mol Microbiol 64: 923-937 Abstract Commentary

Engh I, Würtz C, Witzel-Schlömp K, Zhang HY, Hoff B, Nowrousian M, Rottensteiner H, Kück U (2007) The WW domain protein PRO40 is required for fungal fertility and associates with Woronin bodies. Eukaryot Cell 6: 831-843 Abstract

Nowrousian M, Piotrowski M, Kück U (2007) Multiple layers of temporal and spatial control regulate accumulation of the fruiting body-specific protein APP in Sordaria macrospora and Neurospora crassa. Fungal Genet Biol 44: 602-614 Abstract


Nowrousian M, Kück U (2006) Comparative gene expression analysis of fruiting body development in two filamentous fungi. FEMS Microbiol Lett 257: 328-335 Abstract

Pöggeler S, Nowrousian M, Ringelberg C, Loros JJ, Dunlap JC, Kück U (2006) Microarray and real time PCR analyses reveal mating type-dependent gene expression in a homothallic fungus. Mol Genet Genomics 275: 492-503 Abstract


Balczun C, Bunse A, Nowrousian M, Korbel A, Glanz S, Kück U (2005) DNA macroarray and real-time PCR analysis of two nuclear photosystem I mutants from Chlamydomonas reinhardtii reveal downregulation of Lhcb genes but different regulation of Lhca genes. Biochim Biophys Acta 1732: 62-68 Abstract

Nowrousian M, Cebula P (2005) The gene for a lectin-like protein is transcriptionally activated during sexual development, but is not essential for fruiting body formation in the filamentous fungus Sordaria macrospora. BMC Microbiology 5: 64 Abstract pdf-file

Nowrousian M, Ringelberg C, Dunlap JC, Loros JJ, Kück U (2005) Cross-species microarray hybridization to identify developmentally regulated genes in the filamentous fungus Sordaria macrospora. Mol Genet Genomics 273: 137-149 Abstract


Nowrousian M, Würtz C, Pöggeler S, Kück U (2004) Comparative sequence analysis of Sordaria macrospora and Neurospora crassa as a means to improve genome annotation. Fungal Genet Biol 41: 285-292 Abstract


Nowrousian M, Duffield GE, Loros JJ, Dunlap JC (2003) The frequency gene is required for temperature-dependent regulation of many clock-controlled genes in Neurospora crassa. Genetics 164: 923-933 Abstract pdf-file


Zhu H*, Nowrousian M*, Kupfer D, Colot HV, Berrocal-Tito G, Lai H, Bell-Pedersen D, Roe BA, Loros JJ, Dunlap JC (2001) Analysis of expressed sequence tags from two starvation, time-of-day-specific libraries of Neurospora crassa reveals novel clock-controlled genes. Genetics 157: 1057-1065. *equal contribution. Abstract pdf-file


Nowrousian M, Kück U, Loser K, Weltring KM (2000) The fungal acl1 and acl2 genes encode two polypeptides with homology to the N- and C-terminal parts of the animal ATP citrate lyase polypeptide. Curr Gen 37:189-193 Abstract


Nowrousian M, Masloff S, Pöggeler S, Kück U (1999) Cell differentiation during sexual development of the fungus Sordaria macrospora requires ATP citrate lyase activity. Mol Cell Biol 19: 450-460 Abstract pdf-file


Nowrousian M, Kück U (1998) Isolation and cloning of the Sordaria macrospora ura3 gene and its heterologous expression in Aspergillus niger. Fungal Genetics Newsletter 45: 34-37 pdf-file


Pöggeler S, Nowrousian M, Jacobsen S, Kück U (1997) An efficient procedure to isolate fungal genes from an indexed cosmid library. J Microbiol Meth 29: 49-61 Abstract


Hörandl E, Bast J, Brandt A, Scheu S, Bleidorn C, Cordellier M, Nowrousian M, Begerow D, Sturm A, Verhoeven K, Boenigk J, Friedl T, Dunthorn M (2020) Genome evolution of asexual organisms and the paradox of sex in eukaryotes. In: Pontarotti P (ed) Evolutionary biology - a transdisciplinary approach, Springer-Verlag Berlin-Heidelberg, p. 133-167

Teichert I, Pöggeler S, Nowrousian M (2020) Sordaria macrospora: 25 years as a model organism for studying the molecular mechanisms of fruiting body development. Appl Microbiol Biotechnol 104: 3691-3704 Review at Appl Microbiol Biotechnol

Nowrousian M (2018) Genomics and transcriptomics to study fruiting body development: an update. Fungal Biol Rev 32: 231-235 Abstract

Pöggeler S, Nowrousian M, Teichert I, Beier A, Kück U (2018) Fruiting body development in ascomycetes. In: Anke T, Schüffler A (eds) The Mycota XV, Physiology and Genetics, 2nd edition, Springer-Verlag Berlin-Heidelberg, p. 1-56

Kück U, Nowrousian M (2015) Von Maxam-Gilbert und Sanger zur Next Generation-Sequenzierung. BIOspektrum (01/2015) 21: 25-27

Teichert I, Nowrousian M, Pöggeler S, Kück U (2014) The filamentous fungus Sordaria macrospora as a genetic model to study fruiting body development. Adv Genet 87: 199-244 Abstract

Nowrousian M (2014) Genomics and transcriptomics to analyze fruiting body development. In: Nowrousian M (ed) The Mycota XIII, Fungal Genomics, 2nd edition, Springer-Verlag Berlin-Heidelberg, p. 149-172

Nowrousian M (ed) (2014) The Mycota XIII, Fungal Genomics, 2nd edition, Springer-Verlag Berlin-Heidelberg

Nowrousian M (2014) Laser-Mikrodissektion und RNA-seq zur Analyse der Genexpression in Pilzen. BIOspektrum (01/2014) 20: 30-32

Nowrousian M (2013) Genomsequenzierung zur Identifikation von Mutationen. BIOspektrum (01/2013) 19: 25-27

Teichert I, Nowrousian M (2011) Evolution of genes for secondary metabolism in fungi. In: Pöggeler S, Wöstemeyer J (eds) The Mycota XIV, Evolution of fungi and fungal-like organisms, Springer-Verlag Berlin-Heidelberg, p. 231-255

Nowrousian M (2010) Next-generation sequencing techniques for eukaryotic microorganisms: sequencing-based solutions to biological problems. Eukaryot Cell 9: 1300-1310 Abstract pdf

Engh I, Nowrousian M, Kück U (2010) Sordaria macrospora, a model organism to study fungal cellular development. Eur J Cell Biol 89: 864-872 Abstract

Kück U, Pöggeler S, Nowrousian M, Nolting N, Engh I (2009) Sordaria macrospora, a model system for fungal development. In: Anke T, Weber D (eds) The Mycota XV, Physiology and Genetics, 1st edition, Springer-Verlag Berlin-Heidelberg, p. 17-39 pdf-file

Nowrousian M (2007) Of patterns and pathways: microarray technologies for the analysis of filamentous fungi. Fungal Biol Rev 21: 171-178

Nowrousian M (2007) Neurospora crassa als Modellorganismus im "postgenomischen" Zeitalter. BIOspektrum (07/2007) 13: 708-712

Pöggeler S, Nowrousian M, Kück U (2006) Fruiting-body development in ascomycetes. In: Kües, Fischer (ed) The Mycota I, Growth, Differentiation and Sexuality, 2nd edition, Springer-Verlag Berlin-Heidelberg, p. 325-355

Nowrousian M, Dunlap JC, Nelson MA (2004) Functional Genomics in Fungi. In: Kück (ed) The Mycota II, Genetics and Biotechnology, 2nd edition, Springer-Verlag Berlin-Heidelberg, p. 115-128

Froehlich AC, Pregueiro A, Lee K, Denault D, Colot H, Nowrousian M, Loros JJ, Dunlap JC (2003) The molecular workings of the Neurospora biological clock. In: Chadwick DJ, Goode JA (eds) Molecular clocks and light signalling, Novartis Found Symp 253, Wiley, Chichester, p. 184-202 Abstract

Contributions to textbooks

Kück U, Nowrousian M, Hoff B, Engh I (2009) Schimmelpilze. Springer-Verlag Berlin-Heidelberg

Kück (ed) Praktikum der Molekulargenetik (2005), Springer-Verlag Berlin-Heidelberg

Seyffert (ed) Lehrbuch der Genetik, 2. Auflage (2003), Spektrum-Verlag, Heidelberg